Optimization of asymmetric bioreduction conditions of 1-indanone by Leuconostoc mesenteroides N6 using a face-centered design-based multi-objective optimization model

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dc.contributor.authorAlamoudi, Mohammed
dc.contributor.authorOzdemir, Akin
dc.contributor.authorDertli, Enes
dc.contributor.authorBolubaid, Mohammed
dc.contributor.authorAlidrisi, Hassan M.
dc.contributor.authorTaylan, Osman
dc.contributor.authorYilmaz, Mustafa Tahsin
dc.date.accessioned2024-10-04T18:52:33Z
dc.date.available2024-10-04T18:52:33Z
dc.date.issued2024
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThere has been an increasing interest in biocatalysts over the past few decades in order to obtain high efficiency, high yield, and environmentally benign procedures aiming at the manufacture of pharmacologically relevant chemicals. Lactic Acid Bacteria (LAB), a microbial group, can be employed as biocatalysts while performing asymmetric reduction of prochiral ketones. In this study, Leuconostoc mesenteroides N6 was used for the asymmetric bioreduction 1-indanone. And then, a novel and innovative face-centered design-based multi-objective optimization model was used to optimize experimental conditions. Also, the experimental design factors were defined as agitation speed, incubation period, pH, and temperature for optimization to acquire the maximum enantiomeric excess (ee) and conversion rate (cr) values. When using the face-centered design-based multi-objective optimization model, the optimum culture conditions corresponded to 96.34 and 99.42%, ee and cr responses, respectively, were pH = 5.87, incubation temperature = 35 degrees C, incubation period = 50.88 h, and agitation speed = 152.60 rpm. Notably, the validation experiment under the optimum model conditions confirmed the model results. This study demonstrated the importance of the optimization and the efficiency of the face-centered design-based multi-objective model.en_US
dc.description.sponsorshipDeanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, Saudi Arabia [RG-27-135-42]en_US
dc.description.sponsorshipThis research work was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, Saudi Arabia, under grant No. (RG-27-135-42).en_US
dc.identifier.doi10.1080/10826068.2023.2201942
dc.identifier.endpage18en_US
dc.identifier.issn1082-6068
dc.identifier.issn1532-2297
dc.identifier.issue1en_US
dc.identifier.pmid37083050en_US
dc.identifier.scopus2-s2.0-85153482637en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage12en_US
dc.identifier.urihttps://doi.org/10.1080/10826068.2023.2201942
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3544
dc.identifier.volume54en_US
dc.identifier.wosWOS:000973287500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofPreparative Biochemistry & Biotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBioreductionen_US
dc.subjectlactic acid bacteriaen_US
dc.subjectLeuconostoc mesenteroides N6en_US
dc.subjectoptimizationen_US
dc.subject(S)-1-indanolen_US
dc.titleOptimization of asymmetric bioreduction conditions of 1-indanone by Leuconostoc mesenteroides N6 using a face-centered design-based multi-objective optimization modelen_US
dc.typeArticleen_US

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