Investigation of The Relationship Between COVID-19 Severity and Serum Adropin Levels

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dc.contributor.authorÖzçelik, Cihad
dc.contributor.authorHalıcı, Hamza
dc.contributor.authorTör, İbrahim Hakkı
dc.contributor.authorUzunçakmak, Sevgi Karabulut
dc.contributor.authorAydın, Pelin
dc.date.accessioned2026-02-28T12:42:46Z
dc.date.available2026-02-28T12:42:46Z
dc.date.issued2024
dc.departmentBayburt Üniversitesi
dc.description.abstractAbstract Aim: COVID-19 is a multisystemic disease with high mortality and morbidity. It is very important to understand the pathogenesis of the disease and to develop pharmacological treatment methods. The aim of this study was to measure serum adropin levels in COVID-19 patients in the ward and intensive care unit and to investigate whether this value can be a prognostic factor or a pharmacological treatment target. Materials and Methods: 116 volunteer participants were included in the study. Participants were grouped as the control group consisting of patients without any disease, patients diagnosed with COVID-19 and hospitalised in the ward, patients diagnosed with COVID-19 and hospitalised in Level 2 intensive care and patients diagnosed with COVID-19 and hospitalised in Level 3 intensive care. Venous blood was taken from the patients. Serum adropin levels were measured according to the manufacturer's instructions. ROC analysis was also performed. Results: According to serum adropin measurements, serum adropin levels of patients with COVID-19 who were hospitalised in the ward decreased compared to the control group.(p<0.05). In Level 2 intensive care and Level 3 intensive care patients, serum adropin levels decreased compared to patients in the ward.(p<0.05) According to Roc analysis, 333.1 ng/L adropin had a specificity of 0.8167 (95%, 0.6956-0.9048) and a sensitivity of 0.6522 (95%, 0.4273-0.8362). Conclusion: COVID-19 is a disease with high mortality and morbidity affecting all systems. With this study, we think that serum adropin levels may be a prognostic factor or a new pharmacological treatment target and may shed light on new studies.
dc.identifier.doi10.5281/zenodo.10712299
dc.identifier.endpage20
dc.identifier.issn3023-6991
dc.identifier.issue1
dc.identifier.startpage15
dc.identifier.urihttps://doi.org/10.5281/zenodo.10712299
dc.identifier.urihttps://hdl.handle.net/20.500.12403/7703
dc.identifier.volume1
dc.language.isoen
dc.publisherAtatürk Üniversitesi
dc.relation.ispartofCurrent Research in Health Sciences
dc.relation.ispartofCurrent Research in Health Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20260218
dc.subjectMedical Pharmacology
dc.subjectTıbbi Farmakoloji
dc.subjectAnaesthesiology
dc.subjectAnesteziyoloji
dc.titleInvestigation of The Relationship Between COVID-19 Severity and Serum Adropin Levels
dc.typeArticle

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