Effects of two lichen acids isolated from Pseudevernia furfuracea (L.) Zopf in cultured human lymphocytes

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dc.authoridEmsen, Bugrahan/0000-0002-9636-2596
dc.authoridaslan, ali/0000-0002-5122-6646
dc.contributor.authorEmsen, Bugrahan
dc.contributor.authorTogar, Basak
dc.contributor.authorTurkez, Hasan
dc.contributor.authorAslan, Ali
dc.date.accessioned2024-10-04T18:49:40Z
dc.date.available2024-10-04T18:49:40Z
dc.date.issued2018
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThe present study aims at assessing the efficacies of olivetoric acid (OA) and physodic acid (PA) isolated from Pseudevernia furfuracea (L.) Zopf (Parmeliaceae) in human lymphocytes (HLs) in vitro. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and lactate dehydrogenase assays were performed to establish cytotoxicity in HLs. Besides, oxidative stress and genotoxicity were monitored by estimating the changes of total oxidative stress (TOS) and 8-hydroxy-2'-deoxyguanosine (8-OH-dG) levels, respectively, in HLs. At the same time, OA- and PA-induced total antioxidant capacity (TAC) levels in HLs were determined. Although especially low concentrations of OA (IC50 = 109.94 mg/L) and PA (IC50 = 665.49 mg/L) did not show cytotoxic effect at high levels in HLs, it was revealed that cytotoxicity was significantly (p < 0.05) associated with oxidative stress and genotoxicity via correlation analysis. While TOS level in HLs did not statistically (p > 0.05) increase in the presence of all treatments (0.5-100 mg/L) of PA, TAC level was increased by PA applications in certain concentrations (0.5-10 mg/L). Overall, the obtained data indicate that OA and especially PA as lichen compounds that do not cause oxidative stress can be a new resource of therapeutics as recognized in the present study with their high antioxidant features.en_US
dc.identifier.doi10.1515/znc-2017-0209
dc.identifier.endpage312en_US
dc.identifier.issn0939-5075
dc.identifier.issn1865-7125
dc.identifier.issue7-8en_US
dc.identifier.pmid29573381en_US
dc.identifier.scopus2-s2.0-85045849753en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage303en_US
dc.identifier.urihttps://doi.org/10.1515/znc-2017-0209
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3250
dc.identifier.volume73en_US
dc.identifier.wosWOS:000437980200007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofZeitschrift Fur Naturforschung Section C-A Journal of Biosciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidant capacityen_US
dc.subjectcytotoxicityen_US
dc.subjectgenotoxicityen_US
dc.subjectlichenen_US
dc.subjectoxidative stressen_US
dc.titleEffects of two lichen acids isolated from Pseudevernia furfuracea (L.) Zopf in cultured human lymphocytesen_US
dc.typeArticleen_US

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