Regulation of DNA methylation in lesional tissue of children with atopic dermatitis

Basit Öğe Kaydı
dc.authorid0000-0002-3708-2412
dc.contributor.authorKartal, Demet
dc.contributor.authorDirican, Muhammed Hanefi
dc.contributor.authorTaheri, Serpil
dc.contributor.authorMemis, Mehmet
dc.contributor.authorSolak, Eda Oksum
dc.contributor.authorCinar, Salih Levent
dc.contributor.authorBorlu, Murat
dc.date.accessioned2026-02-28T12:18:12Z
dc.date.available2026-02-28T12:18:12Z
dc.date.issued2025
dc.departmentBayburt Üniversitesi
dc.description.abstractBackground Genetic and epigenetic mechanisms have been shown to play a role in the pathogenesis of atopic dermatitis (AD). However, the role of genes involved in the establishment of DNA methylation has not yet been demonstrated.Methods A total of 15 pediatric patients with AD and 15 healthy volunteers were included in this study. The mRNA gene expression levels of eight different genes involved in the regulation of DNA methylation were examined in the blood and tissue samples.Results The mRNA expression levels of DNMT3A genes were significantly increased, while the mRNA expression levels of DNMT3B, TET1, and TET2 genes were statistically significantly reduced in the lesional tissue of patients compared to the control group. It was observed that the mRNA expression levels of DNMT1, DNMT3A, and TET3 genes were increased, while the mRNA expression levels of DNMT3L and TET1 genes were found to be decreased in the blood of the patients.Conclusion The results indicated that the DNA methylation pattern in the patients was hypermethylated, especially in the lesional tissue. The data obtained may contribute to the understanding of the epigenetic regulation of AD and aid in the development of new diagnostic and treatment options.
dc.description.sponsorshipErciyes University Scientific Research Projects Unit [TTU-2021-11212]
dc.description.sponsorshipThe author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This research was funded by the Erciyes University Scientific Research Projects Unit (TTU-2021-11212).
dc.identifier.doi10.3389/fmed.2025.1531777
dc.identifier.issn2296-858X
dc.identifier.pmid40098928
dc.identifier.scopus2-s2.0-105000499991
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3389/fmed.2025.1531777
dc.identifier.urihttps://hdl.handle.net/20.500.12403/6167
dc.identifier.volume12
dc.identifier.wosWOS:001445922600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260218
dc.subjectatopic dermatitis
dc.subjectDNA methylation
dc.subjectTET1-2 and DNMT gene expression
dc.subjectepigenetic
dc.subjectpediatric atopic dermatitis
dc.titleRegulation of DNA methylation in lesional tissue of children with atopic dermatitis
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu