Natural products of relevance in the management of attention deficit hyperactivity disorder

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dc.authoridSharopov, Farukh/0000-0003-0378-8887
dc.authoridSharifi-Rad, Javad/0000-0002-7301-8151
dc.authoridCalina, Daniela/0000-0002-1523-9116
dc.contributor.authorCustodio, Luisa
dc.contributor.authorVizetto-Duarte, Catarina
dc.contributor.authorCebeci, Fatma
dc.contributor.authorOzcelik, Beraat
dc.contributor.authorSharopov, Farukh
dc.contributor.authorGurer, Eda Sonmez
dc.contributor.authorKumar, Manoj
dc.date.accessioned2024-10-04T18:52:31Z
dc.date.available2024-10-04T18:52:31Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractAttention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders characterized by motor hyperactivity, attention deficit, distraction, impulsive behavior, and relationship difficulties. It affects children, and thus over the years, there has been growing attention on the use of natural product formulations and their naturally-occurring bioactive for overcoming the problem of ADHD. Concerning this issue, this review aims to discuss the ADHD treatment potential of natural products/formulations in vitro, in vivo as well as in clinical trials. To gather the most relevant data regarding bioactive compounds with potential therapeutic effects in the management of ADHD, the following databases were searched: PubMed/MedLine, ScienceDirect, and Google Scholar for articles in English. Various medicinal plants and their isolated biomolecules have been evaluated in vitro, in vivo, and in clinical trials for their ability to treat ADHD. Most of the analyzed research results showed an improvement of ADHD signs and symptoms in in vivo models, but the molecular mechanisms of action of the bioactive compounds are unclear and incompletely elucidated. Further studies are needed to determine the bioactive compound responsible for health-promoting effects in ADHD. In addition, clinical studies should be performed over longer periods with more participants.en_US
dc.description.sponsorshipFCT Scientific Employment Stimulus [CEECIND/00425/2017]en_US
dc.description.sponsorshipLuisa Custodio was supported by the FCT Scientific Employment Stimulus (CEECIND/00425/2017). This research received no external funding.en_US
dc.identifier.doi10.1002/efd2.57
dc.identifier.issn2666-3066
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85147213223en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1002/efd2.57
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3513
dc.identifier.volume4en_US
dc.identifier.wosWOS:001191742300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEfooden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectADHDen_US
dc.subjectclinical studiesen_US
dc.subjectnatural productsen_US
dc.subjectpharmacotherapeutic managementen_US
dc.subjectpreclinical studiesen_US
dc.titleNatural products of relevance in the management of attention deficit hyperactivity disorderen_US
dc.typeReview Articleen_US

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