Production of Gamma-Aminobutyric Acid by Levilactobacillus brevis AK19B: Strain Characterization and Process Optimization Using Box-Behnken Design

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dc.contributor.authorMemis, Habibe
dc.contributor.authorKamiloglu, Aybike
dc.date.accessioned2026-09-01T15:53:09Z
dc.date.available2026-09-01T15:53:09Z
dc.date.issued2026
dc.departmentBayburt Üniversitesi
dc.description.abstractLevilactobacillus brevis AK19B strain demonstrated promising probiotic potential as a hydrophilic lactic acid bacterium with valuable phytase activity. It also exhibited strong antioxidant properties and maintained viability in bile salt-rich environments, suggesting robustness in gastrointestinal conditions. To maximize gamma-aminobutyric acid (GABA) production, a Box-Behnken design was applied to assess the effects of monosodium glutamate (MSG) concentration, NaCl concentration, pH, and temperature. The results showed that these factors significantly influenced GABA synthesis, with their interactions well-modeled by a quadratic response surface. Optimal conditions were identified as pH 5.136, MSG concentration of 297 mM, temperature at 26 degrees C, and NaCl concentration of 2.82%, under which the predicted GABA production reached 43.85 mg/mL. These findings highlight AK19B as a promising candidate for functional food applications and industrial GABA biosynthesis.
dc.description.sponsorshipBayburt University -- Open access funding provided by the Scientific and Technological Research Council of Turkiye (TUB & Idot;TAK).
dc.identifier.doi10.1007/s12602-026-10965-4
dc.identifier.issn1867-1306
dc.identifier.issn1867-1314
dc.identifier.pmid41817892
dc.identifier.scopus2-s2.0-105033385146
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1007/s12602-026-10965-4
dc.identifier.urihttps://hdl.handle.net/20.500.12403/8548
dc.identifier.wosWOS:001712584700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofProbiotics and Antimicrobial Proteins
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260820
dc.subjectLevilactobacillus Brevis
dc.subjectGaba
dc.subjectOptimization
dc.subjectBox-Behnken Design
dc.subjectTechno-Functional Properties
dc.titleProduction of Gamma-Aminobutyric Acid by Levilactobacillus brevis AK19B: Strain Characterization and Process Optimization Using Box-Behnken Design
dc.typeArticle

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