The effect of carvacrol on oxido-inflammatory ovarian injury and infertility induced by ischemia-reperfusion in rats

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dc.contributor.authorSahin, Nurullah
dc.contributor.authorDelibas, Ilhan Bahri
dc.contributor.authorIsaoglu, Unal
dc.contributor.authorSuleyman, Bahadir
dc.contributor.authorYazici, Gulce Naz
dc.contributor.authorCoban, Taha Abdulkadir
dc.contributor.authorUzel, Kemine
dc.date.accessioned2024-10-04T18:53:51Z
dc.date.available2024-10-04T18:53:51Z
dc.date.issued2022
dc.departmentBayburt Üniversitesien_US
dc.description.abstractBackground: Increased oxidants and proinflammatory cytokines play a role in the pathogenesis of ovarian ischemia-reperfusion (OIR) injury and related infertility. Carvacrol has antioxidant, antibacterial and anti-inflammatory properties. Methods: Protective effect of carvacrol against ischemia-reperfusion (IR)-related ovarian damage and infertility was investigated. IR process were applied to the ovaries of rats, which were divided into the following groups (n = 12): OIR, IR +50 mg/kg carvacrol (IRC-50), IR +100 mg/kg carvacrol (IRC-100) and sham group (SG). After the reperfusion process, six rats from each group were killed and the removed ovaries were examined biochemically and histopathologically. The remaining animals were kept two months with mature male rats to reproduce. Results: At a dose of 50 mg/kg, carvacrol suppressed the oxidant parameter increase and antioxidant decrease caused by IR in ovarian tissue. At a dose of 100 mg/kg, carvacrol antagonized both oxidant and proinflammatory cytokine increase and antioxidant decrease. Histopathologically, severe degeneration of follicles in the ovaries of the OIR group, necrotic cell accumulations, hemorrhage in the corpus luteum, edema in the interstitial tissue, polymorphous nuclear leukocyte (PNL) infiltration, and congestion and dilation of blood vessels were detected. Inflammatory symptoms such as edema in the ovarian tissue, congested dilated blood vessels and PNL infiltration were observed at a dose of 50 mg/kg of carvacrol, but these histopathological findings were not observed at a dose of 100 mg/kg. Conclusion: A dose of 100 mg/kg carvacrol, which eliminated inflammatory damage, significantly prevented the development of IRinduced infertility. Carvacrol may be beneficial in the treatment of IR-related ovarian damage and infertility.en_US
dc.identifier.doi10.31083/j.ceog4903058
dc.identifier.issn0390-6663
dc.identifier.issn2709-0094
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85127470040en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.31083/j.ceog4903058
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3754
dc.identifier.volume49en_US
dc.identifier.wosWOS:000780771900012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherImr Pressen_US
dc.relation.ispartofClinical and Experimental Obstetrics & Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarvacrolen_US
dc.subjectOxido-inflammatoryen_US
dc.subjectInfertilityen_US
dc.subjectRaten_US
dc.titleThe effect of carvacrol on oxido-inflammatory ovarian injury and infertility induced by ischemia-reperfusion in ratsen_US
dc.typeArticleen_US

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