Methoxy-activated indole-7-carbohydrazides
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
HeteroCorporation
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Indole has been known as a key heterocyclic motif in the development of new structures for both chemical and biological properties. In this current study, a new range of indole-7-carbohydrazides has been successfully synthesized starting from the readily available 3-phenyl and 2,3-diphenyl 4,6-dimethoxyindoles. The structures of the novel compounds were confirmed by utilizing 1H NMR, 13C NMR, FT-IR, high-resolution mass spectrometry, and single crystal X- ray diffraction techniques. In addition, the indole-7-carbohydrazides showed promising antioxidant results in preliminary screens. Some of the new compounds generated from dimethoxy indoles were also screened for their anticancer activity against SH-SHY5Y (human neuroblastoma), AGS (human gastric adenocarcinoma), and MDA-MB-231 (human breast adenocarcinoma) cell lines. The results revealed that the compound 12 was the promising candidate, showing cytotoxic effects on both neuroblastoma, stomach, and breast cancer cells. © 2022 Wiley Periodicals LLC.
Açıklama
Anahtar Kelimeler
2 3 diphenyl indole, 2 3 phenyl dimethoxyindole derivative, 3 diphenyl 4 6 dimethoxyindole derivative, 3 phenyl indole, 7 (hydrazonomethyl) 4 6 dimethoxy 2 3 diphenyl 1h indole, 7 (hydrazonomethyl) 4 6 dimethoxy 3 phenyl 1h indole, hydrazide derivative, indole 7 carbohydrazide derivative, indole derivative, indometacin, melatonin, n ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene) 3 (trifluoromethyl)benzohydrazide, n ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene) 4 methylbenzohydrazide, n ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene) 4 nitrobenzohydrazide, n ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene)acetohydrazide, n ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene)benzohydrazide, n ([4 6 dimethoxy 3 phenyl 1h indol 7 yl]methylene) 3 (trifluoromethyl)benzohydrazide, n ([4 6 dimethoxy 3 phenyl 1h indol 7 yl]methylene) 4 nitrobenzohydrazide, n ([4 6 dimethoxy 3 phenyl 1h indol 7 yl]methylene)acetohydrazide, oxypertine, unclassified drug, ABTS radical scavenging assay, antineoplastic activity, antioxidant activity, Article, breast adenocarcinoma cell line, carbon nuclear magnetic resonance, cell proliferation, cell viability, controlled study, cytotoxicity, DPPH radical scavenging assay, drug synthesis, female, Fourier transform infrared spectroscopy, gastric adenocarcinoma cell line, human, mass spectrometry, neuroblastoma cell line, proton nuclear magnetic resonance, X ray diffraction
Kaynak
Journal of Heterocyclic Chemistry
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
60
Sayı
1
