Methoxy-activated indole-7-carbohydrazides

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dc.contributor.authorKandemir, Hakan
dc.contributor.authorİzgi, Samet
dc.contributor.authorCınar, Irfan
dc.contributor.authorCebeci, Fatma
dc.contributor.authorDırıcan, Ebubekir
dc.contributor.authorSaglam, Mehmet F.
dc.contributor.authorSengul, Ibrahim Fazil
dc.date.accessioned2026-02-28T12:08:56Z
dc.date.available2026-02-28T12:08:56Z
dc.date.issued2023
dc.departmentBayburt Üniversitesi
dc.description.abstractIndole has been known as a key heterocyclic motif in the development of new structures for both chemical and biological properties. In this current study, a new range of indole-7-carbohydrazides has been successfully synthesized starting from the readily available 3-phenyl and 2,3-diphenyl 4,6-dimethoxyindoles. The structures of the novel compounds were confirmed by utilizing 1H NMR, 13C NMR, FT-IR, high-resolution mass spectrometry, and single crystal X- ray diffraction techniques. In addition, the indole-7-carbohydrazides showed promising antioxidant results in preliminary screens. Some of the new compounds generated from dimethoxy indoles were also screened for their anticancer activity against SH-SHY5Y (human neuroblastoma), AGS (human gastric adenocarcinoma), and MDA-MB-231 (human breast adenocarcinoma) cell lines. The results revealed that the compound 12 was the promising candidate, showing cytotoxic effects on both neuroblastoma, stomach, and breast cancer cells. © 2022 Wiley Periodicals LLC.
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK, (120Z116); Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK; Tekirdağ Namık Kemal Üniversitesi, TNKU, (19.220, NKUBAP.01); Tekirdağ Namık Kemal Üniversitesi, TNKU
dc.identifier.doi10.1002/jhet.4562
dc.identifier.endpage85
dc.identifier.issn0022152X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85137568357
dc.identifier.scopusqualityQ2
dc.identifier.startpage74
dc.identifier.urihttps://doi.org/10.1002/jhet.4562
dc.identifier.urihttps://hdl.handle.net/20.500.12403/5724
dc.identifier.volume60
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherHeteroCorporation
dc.relation.ispartofJournal of Heterocyclic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20260218
dc.subject2 3 diphenyl indole
dc.subject2 3 phenyl dimethoxyindole derivative
dc.subject3 diphenyl 4 6 dimethoxyindole derivative
dc.subject3 phenyl indole
dc.subject7 (hydrazonomethyl) 4 6 dimethoxy 2 3 diphenyl 1h indole
dc.subject7 (hydrazonomethyl) 4 6 dimethoxy 3 phenyl 1h indole
dc.subjecthydrazide derivative
dc.subjectindole 7 carbohydrazide derivative
dc.subjectindole derivative
dc.subjectindometacin
dc.subjectmelatonin
dc.subjectn ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene) 3 (trifluoromethyl)benzohydrazide
dc.subjectn ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene) 4 methylbenzohydrazide
dc.subjectn ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene) 4 nitrobenzohydrazide
dc.subjectn ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene)acetohydrazide
dc.subjectn ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene)benzohydrazide
dc.subjectn ([4 6 dimethoxy 3 phenyl 1h indol 7 yl]methylene) 3 (trifluoromethyl)benzohydrazide
dc.subjectn ([4 6 dimethoxy 3 phenyl 1h indol 7 yl]methylene) 4 nitrobenzohydrazide
dc.subjectn ([4 6 dimethoxy 3 phenyl 1h indol 7 yl]methylene)acetohydrazide
dc.subjectoxypertine
dc.subjectunclassified drug
dc.subjectABTS radical scavenging assay
dc.subjectantineoplastic activity
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectbreast adenocarcinoma cell line
dc.subjectcarbon nuclear magnetic resonance
dc.subjectcell proliferation
dc.subjectcell viability
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectDPPH radical scavenging assay
dc.subjectdrug synthesis
dc.subjectfemale
dc.subjectFourier transform infrared spectroscopy
dc.subjectgastric adenocarcinoma cell line
dc.subjecthuman
dc.subjectmass spectrometry
dc.subjectneuroblastoma cell line
dc.subjectproton nuclear magnetic resonance
dc.subjectX ray diffraction
dc.titleMethoxy-activated indole-7-carbohydrazides
dc.title.alternativesynthesis, antioxidant, and anticancer properties
dc.typeArticle

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