Candida zeylanoides as whole-cell biocatalyst to perform asymmetric bioreduction of benzophenone derivatives

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dc.authorid0000-0002-3723-1705en_US
dc.contributor.authorŞahin, Engin
dc.date.accessioned2020-11-25T19:44:18Z
dc.date.available2020-11-25T19:44:18Z
dc.date.issued2020en_US
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractCandida zeylanoides P1 was investigated as whole cell biocatalyst for the bioreduction of biaryl prochiral ketones into chiral carbinols, which can be used as pharmaceutical intermediate. Bioreduction of different biaryl ketones was carried out to their corresponding chiral biaryl carbinols such as (S)-(4-chlorophenyl) (phenyl) methanol (2a), which can be used in the synthesis of L-cloperastine drug, with antitussive, antiepidemic activity and bronchial musculature relaxant characteristics, in gram scale, enantiopure form (>99%) and excellent yields. The selectivity of C. zeylanoides P1 in enantioselective reduction of biaryl ketones was not affected by the steric and electronic effects of substrates. The current method demonstrates an encouraging green chemistry approach for the production of biaryl secondary chiral alcohols of pharmaceutical importance in mild, inexpensive and environmentally friendly process. The present study has many benefits since this yeast biocatalyst were successfully applied bioreduction of structurally bulky prochiral substrates, which cannot be reducted by chemical catalysis.en_US
dc.identifier.citationŞahin, E. (2020). Candida zeylanoides as whole-cell biocatalyst to perform asymmetric bioreduction of benzophenone derivatives. Synthetic Communications, 50(4), 612-619.en_US
dc.identifier.doi10.1080/00397911.2019.1710213
dc.identifier.endpage619en_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85078615251en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage612en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/00397911.2019.1710213?casa_token=QCJr5f1zwGIAAAAA%3A6Au_3PLhaZmpF_sqckEAGDcaW1oCHST0WaJJGNDvAZ4uHEEROVfZXvq5ILUFZHpYoivpbIFZbBNSH7Q
dc.identifier.urihttps://hdl.handle.net/20.500.12403/2225
dc.identifier.volume50en_US
dc.identifier.wosWOS:000506571000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSynthetic Communicationsen_US
dc.relation.ispartofSynthetic Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectChiralityen_US
dc.subjectCandida zeylanoidesen_US
dc.subjectchiral benzophenone carbinolsen_US
dc.subjectenantioselective reductionen_US
dc.subject(S)-(4-chlorophenyl) (phenyl) methanolen_US
dc.titleCandida zeylanoides as whole-cell biocatalyst to perform asymmetric bioreduction of benzophenone derivativesen_US
dc.typeArticleen_US

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