Synthesis of 7-azaindole based carbohydrazides and 1,3,4-oxadiazoles; Antioxidant activity, ?-glucosidase inhibition properties and docking study

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dc.authoridKOCA, MEHMET SERDAR/0009-0001-4589-4218
dc.contributor.authorIzgi, Samet
dc.contributor.authorSengul, Ibrahim F.
dc.contributor.authorSahin, Engin
dc.contributor.authorKoca, Mehmet Serdar
dc.contributor.authorCebeci, Fatma
dc.contributor.authorKandemir, Hakan
dc.date.accessioned2024-10-04T18:53:49Z
dc.date.available2024-10-04T18:53:49Z
dc.date.issued2022
dc.departmentBayburt Üniversitesien_US
dc.description.abstractIn this current work, 7-azaindole based 1,3,4-oxadiazoles have been successfully prepared by treatment of 3-(hydrazonomethyl)-7-azaindole with the different acyl chlorides or acetic anhydrides to give the cor-responding carbohydrazides, followed by iodine mediated synthetic protocol in order to afford the corresponding 2,5-disubstituted 1,3,4-oxadiazoles. The full characterization data of the novel compounds were obtained by utilizing H-1 NMR, C-13 NMR, FT-IR, high-resolution mass spectrometry and single crystal X-ray diffraction techniques. The antioxidant activity and alpha-glucosidase inhibition potential of the prepared compounds are examined by in vitro assays. The targeted hydrazide linked 7-azaindoles and their corresponding cyclized form 1,3,4-oxadiazoles exhibited inhibitory potential with IC50 values ranges between 0.46 and 24.92 mM. Plausible binding mode and interaction of ligands with alpha-glucosidase enzyme have been studied by molecular docking, supporting the experimental results. (C) 2021 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [120Z116]; Tekirdag Namk Kemal University [NKUBAP.01, 19.220]en_US
dc.description.sponsorshipThis work has been supported by The Scientific and Technological Research Council of Turkey (Project Number: 120Z116) and Tekirdag Namk Kemal University (Project Number: NKUBAP.01.GA.19.220) .en_US
dc.identifier.doi10.1016/j.molstruc.2021.131343
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85114035627en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2021.131343
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3721
dc.identifier.volume1247en_US
dc.identifier.wosWOS:000709586500009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject7-azaindoleen_US
dc.subject1,3,4-oxadiazoleen_US
dc.subjectalpha-glucosidase inhibitionen_US
dc.subjectAntioxidant activityen_US
dc.subjectDocking studyen_US
dc.titleSynthesis of 7-azaindole based carbohydrazides and 1,3,4-oxadiazoles; Antioxidant activity, ?-glucosidase inhibition properties and docking studyen_US
dc.typeArticleen_US

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