Catecholaminergic and Cholinergic Systems Mediate Beneficial Effect of Vortioxetine on Diabetes-Induced Neuropathic Pain

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dc.authoridTURAN YUCEL, NAZLI/0000-0002-0371-2703
dc.authoridUcel, Umut Irfan/0000-0002-5470-0139
dc.authoridDemir Ozkay, Umide/0000-0002-6773-4266
dc.authoridKandemir, Ummuhan/0000-0003-3314-1961
dc.contributor.authorTuran Yucel, Nazli
dc.contributor.authorKandemir, Ummuhan
dc.contributor.authorUcel, Umut Irfan
dc.contributor.authorOzkay, Umide Demir
dc.contributor.authorCan, Ozgur Devrim
dc.date.accessioned2024-10-04T18:48:29Z
dc.date.available2024-10-04T18:48:29Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThe therapeutic potential of vortioxetine on mechanical hyperalgesia/allodynia was investigated in rats with streptozotocin-induced diabetes, and its possible mechanism of action was elucidated in this study. The obtained findings demonstrated that subacute vortioxetine treatment (5 and 10 mg/kg for 2 weeks) increased the reduced paw-withdrawal thresholds of diabetic rats both in the Randall-Selitto and Dynamic plantar tests. Moreover, the falling latencies of animals did not change in the Rota-rod assessments. These results suggest that vortioxetine administration significantly improved diabetes-induced hyperalgesia and allodynia responses in the rats without affecting their motor coordination. The vortioxetine (5 mg/kg)-induced antihyperalgesic and antiallodynic effects were reversed by AMPT, yohimbine, ICI 118,551, sulpiride and atropine pre-treatments, suggesting the involvement of the catecholaminergic system, alpha(2)- and beta(2)-adrenoceptors, D-2/3 dopaminergic receptors and cholinergic muscarinic receptors in the exhibited pharmacological activity, respectively. Moreover, the data from the immunohistochemical studies indicated that the inhibition of c-Fos overexpression in dorsal horn neurons also mediates the beneficial effect of this drug. Vortioxetine induced no difference in plasma glucose levels in diabetic rats. If clinical studies confirm these findings, the concomitant beneficial effect of vortioxetine on mood disorders and its neutral activity profile on glycemic control may make it an alternative drug for the treatment of neuropathic pain.en_US
dc.description.sponsorshipAnadolu University Scientific Research Projects Commission [2104S014]en_US
dc.description.sponsorshipThis research received no external funding.en_US
dc.identifier.doi10.3390/biomedicines11041137
dc.identifier.issn2227-9059
dc.identifier.issue4en_US
dc.identifier.pmid37189755en_US
dc.identifier.scopus2-s2.0-85153783562en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/biomedicines11041137
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3068
dc.identifier.volume11en_US
dc.identifier.wosWOS:000977147800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofBiomedicinesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectallodyniaen_US
dc.subjectdiabetesen_US
dc.subjectdynamic plantar testen_US
dc.subjecthyperalgesiaen_US
dc.subjectRandall-Selitto testen_US
dc.subjectvortioxetineen_US
dc.titleCatecholaminergic and Cholinergic Systems Mediate Beneficial Effect of Vortioxetine on Diabetes-Induced Neuropathic Painen_US
dc.typeArticleen_US

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