A Promising Antibacterial Inhibition of Propolis Extracts Against Carbapenem-Resistant Bacteria Isolated From Clinical Samples

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dc.authorid0000-0001-9897-5313
dc.contributor.authorEsertas, Ulku Zeynep
dc.contributor.authorInal, Nese
dc.contributor.authorCan, Zehra
dc.contributor.authorKolayli, Sevgi
dc.date.accessioned2026-02-28T12:17:40Z
dc.date.available2026-02-28T12:17:40Z
dc.date.issued2025
dc.departmentBayburt Üniversitesi
dc.description.abstractThe increasing inadequacy of antibiotics against multidrug-resistant pathogens is a growing concern. In this study, the antibacterial activity of propolis extracts with different phenolic profiles against carbapenem-resistant clinical isolates was investigated. The antimicrobial activity of propolis extract was tested against Acinetobacter baumannii (K17, K16, and K21), Klebsiella pneumoniae (K22, and K19), and Stenotrophomonas maltophilia (E5, E7, and E4) bacterial strains isolated from tracheal aspirate and blood cultures. The total phenolic content and phenolic composition of the extracts were analyzed. Antimicrobial activity values examined according to the disk diffusion method were measured as minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The results showed that all propolis extracts showed different inhibition values against bacterial strains. As a result, the high inhibitory potential of the propolis extracts against resistant bacteria such as A. baumannii, K. pneumoniae, and S. maltophilia is promising for combating infections. However, the study needs to be supported by further randomized clinical studies.
dc.description.sponsorshipSBS BioSolutions commercial joint incorporated company company/(BEE'O)
dc.description.sponsorshipWe would like to thank SBS BioSolutions commercial joint incorporated company company/(BEE'O) (Bee&You) for their assistance in providing the commercial propolis samples.
dc.identifier.doi10.1002/cbdv.202500158
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue12
dc.identifier.pmid40884830
dc.identifier.scopus2-s2.0-105014649117
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/cbdv.202500158
dc.identifier.urihttps://hdl.handle.net/20.500.12403/5902
dc.identifier.volume22
dc.identifier.wosWOS:001560429100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260218
dc.subjectcarbapenem-resistant bacteria
dc.subjectclinical isolated
dc.subjectpropolis
dc.titleA Promising Antibacterial Inhibition of Propolis Extracts Against Carbapenem-Resistant Bacteria Isolated From Clinical Samples
dc.typeArticle

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