First green synthesis of (R)-2-methyl-1-phenylpropan-1-ol using whole-cell Lactobacillus paracasei BD101 biotransformation

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dc.authorid0000-0002-3723-1705en_US
dc.contributor.authorŞahin, Engin
dc.date.accessioned2020-11-25T19:55:03Z
dc.date.available2020-11-25T19:55:03Z
dc.date.issued2020en_US
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractGreen chemistry includes a novel process in the production of drugs precursors and biological active molecules using biocatalysts, so reducing the threats for human sanitary and ecological pollutions. Asymmetric bioreduction of prochiral ketones by biocatalysts is one of the best prevalent used methods in synthetic organic chemistry due to the production of enantiopure chiral carbinols. This study emphasizes the application biocatalyst L paracasei BD101 for enantioselective bioreduction of 2-methyl-1-phenylpropan-1-one ketone, which contain branched alkyl chain, to (R)-2-methyl-1-phenylpropan-1-ol ((R)-2) in high yields and excellent enantiomeric excess (>99%). The scale-up production was performed, and 4.61 g of (R)-2 in enantiopure form was synthesized. L paracasei BD101 was proved to be a substantial biocatalyst in asymmetric bioreduction of a ketone which contains a branched alkyl chain. There is not any work in the literature similar to our study. Hence, it is important to work on filling this gap. This study is the first example for an enantiopure synthesis of (R)-2 by a biocatalyst. The new green method was developed for bioreduction of bulky ketones, which contains a branched alkyl chain, and it approves the synthesis of novel chiral carbinols in an easy, cheap, and environmentally friendly condition using L paracasei BD101.en_US
dc.identifier.citationŞahin, E. (2020). First green synthesis of (R)-2-methyl-1-phenylpropan-1-ol using whole-cell Lactobacillus paracasei BD101 biotransformation. Biocatalysis and Biotransformation, 38(2), 138-143.en_US
dc.identifier.doi10.1080/10242422.2019.1698554
dc.identifier.endpage143en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85076435619en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage188en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/10242422.2019.1698554?casa_token=d8-QHA4QXpwAAAAA%3AmvgT83zQuHUtym-QxcsioPOFFjfCous4kjJCxi4UlmFwumopkWjPxbg4URBgXjEtxvMxVxOiY9ngmNA
dc.identifier.urihttps://hdl.handle.net/20.500.12403/2229
dc.identifier.volume38en_US
dc.identifier.wosWOS:000501039100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBiocatalysis and Biotransformationen_US
dc.relation.ispartofBiocatalysis and Biotransformationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectChirality, biocatalyst, green synthesis, enantioselective bioreduction, (R)-2-methyl-1-phenylpropan-1-olen_US
dc.titleFirst green synthesis of (R)-2-methyl-1-phenylpropan-1-ol using whole-cell Lactobacillus paracasei BD101 biotransformationen_US
dc.typeArticleen_US

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