Production of enantiomerically enriched chiral carbinols using Weissella paramesenteroides as a novel whole cell biocatalyst

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dc.authorid57205710479
dc.authorid37098938400
dc.authorid23100981600
dc.authorid36815706500
dc.contributor.authorTozlu C.
dc.contributor.authorŞahin E.
dc.contributor.authorSerencam H.
dc.contributor.authorDertli E.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:43:00Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:43:00Z
dc.date.issued2019
dc.departmentBayburt Üniversitesien_US
dc.description.abstractIn this study, four bacterial strains were tested for their ability to reduce acetophenones to its corresponding alcohol. Among these strains Weissella paramesenteroides N7 was found to be the most successful biocatalyst to reduce the ketones to the corresponding alcohols. The reaction conditions were systematically optimized for W. paramesenteroides N7 that resulted in high enantioselectivity and conversion rates for the bioreduction. The scale-up asymmetric reduction of 1-(4-methoxyphenyl) propan-1-one (1r) by W. paramesenteroides N7 gave (R)-1-(4-methoxyphenyl) propan-1-ol (2r) with 94% yield and >99% enantiomeric excess. This is the first report showing the synthesis of (R)-1-(4-methoxyphenyl) propan-1-ol (2r) in enantiopure form using a biocatalyst on a gram scale. The whole cell catalyzed the reductions of ketone substrates on the preparative scale, demonstrating that W. paramesenteroides N7 would be a valuable biocatalyst for the preparation of chiral aromatic alcohols of pharmaceutical interest as a promising and alternative green approach. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.identifier.doi10.1080/10242422.2019.1568416
dc.identifier.issn1024-2422
dc.identifier.scopus2-s2.0-85061243370en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://dx.doi.org/10.1080/10242422.2019.1568416
dc.identifier.urihttps://hdl.handle.net/20.500.12403/327
dc.identifier.wosWOS:000477723200008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofBiocatalysis and Biotransformationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectasymmetric synthesis
dc.subjectBiotransformation
dc.subjectchiral carbinols
dc.subjectdrug precursor
dc.subjectenantioselective bioreduction
dc.subjectEnantiomers
dc.subjectEnantioselectivity
dc.subjectKetones
dc.subjectMethanol
dc.subjectReaction rates
dc.subjectAsymmetric synthesis
dc.subjectBio reductions
dc.subjectBiotransformation
dc.subjectchiral carbinols
dc.subjectdrug precursor
dc.subjectBiocatalysts
dc.subjectasymmetric synthesis
dc.subjectBiotransformation
dc.subjectchiral carbinols
dc.subjectdrug precursor
dc.subjectenantioselective bioreduction
dc.subjectEnantiomers
dc.subjectEnantioselectivity
dc.subjectKetones
dc.subjectMethanol
dc.subjectReaction rates
dc.subjectAsymmetric synthesis
dc.subjectBio reductions
dc.subjectBiotransformation
dc.subjectchiral carbinols
dc.subjectdrug precursor
dc.subjectBiocatalysts
dc.titleProduction of enantiomerically enriched chiral carbinols using Weissella paramesenteroides as a novel whole cell biocatalysten_US
dc.typeArticleen_US

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