Investigation of anti-oxidative and anti-genotoxic effects of Origanum vulgare L. essential oil on human lymphocytes in vitro

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dc.authorid53983736200
dc.authorid7003921401
dc.authorid55490650200
dc.authorid36550943200
dc.authorid55771966200
dc.authorid26639133600
dc.contributor.authorCeker S.
dc.contributor.authorAgar G.
dc.contributor.authorNardemir G.
dc.contributor.authorAnar M.
dc.contributor.authorKizil H.E.
dc.contributor.authorAlpsoy L.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:44:35Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:44:35Z
dc.date.issued2012
dc.departmentBayburt Üniversitesien_US
dc.description.abstractOriganum vulgare L. (Lamiaceae) is a flavoring herb widely using around the world. Some preparations and extracts from O. vulgare have been used in Turkish traditional medicine to treat several ailments including digestive disorders and menstrual problems. This study is designed to examine the chemical composition and in vitro antigenotoxic and antioxidant activity of the essential oil of O. vulgare (OVE) from Turkey. The essential oil of O. vulgare was analized by using GC. OVEs that were investigated antagonistic effects against oxidative stress and the genotoxic effects of aflatoksin B1 (AFB1). Anti-genotoxic activity was evaluated by sister chromatid exchanges (SCEs) and micronucleus (MN) tests. In additional to investigating protective role of OVEs against the oxidative stress of AFB1 in vitro, oxidative status was assessed on erythrocytes by measuring following oxidative stress markers like; super oxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA).The total of the 25 identified components are accounted for 96.03 % (GC). Major components of the oil were ?-caryophyllene (20.40%), and caryophyllene oxide (34.44%). In the SCE and MN tests, it was observed that OVEs suppressed the mutagenic effects of AFB1. OVEs were observed to modulate the adverse effects of AFB1. The results of this experiment clearly reveal that OVEs have strong anti-oxidative and anti-genotoxic effect. These anti-genotoxic effects of O. vulgare essential oils are probably related to its action on the enzymatic activation system. Anti-oxidative and anti-genotoxic effect may be role of these compounds (?-caryophyllene and caryophyllene oxide). © 2012, Har Krishan Bhalla & Sons.en_US
dc.identifier.doi10.1080/0972060X.2012.10662604
dc.identifier.endpage1005
dc.identifier.issn0972-060X
dc.identifier.issue6
dc.identifier.scopus2-s2.0-84879315616en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage997
dc.identifier.urihttps://dx.doi.org/10.1080/0972060X.2012.10662604
dc.identifier.urihttps://hdl.handle.net/20.500.12403/891
dc.identifier.volume15
dc.identifier.wosWOS:000321521200018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Essential Oil-Bearing Plantsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAflatoxin B1
dc.subjectAnti-genotoxicity
dc.subjectAntioxidant enzymes
dc.subjectOriganum vulgare
dc.subjectLamiaceae
dc.subjectOriganum
dc.subjectOriganum vulgare
dc.subjectAflatoxin B1
dc.subjectAnti-genotoxicity
dc.subjectAntioxidant enzymes
dc.subjectOriganum vulgare
dc.subjectLamiaceae
dc.subjectOriganum
dc.subjectOriganum vulgare
dc.titleInvestigation of anti-oxidative and anti-genotoxic effects of Origanum vulgare L. essential oil on human lymphocytes in vitroen_US
dc.typeArticleen_US

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