Effect of Different Rates of Rambutan Peel Extract on Visfatin and Cardiac Troponi N I Response in Type 2 Diabetic Rats Induced with Streptozotocin

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dc.contributor.authorTasci, S. celikel
dc.contributor.authorBayraktar, B.
dc.contributor.authorBulbul, A. S.
dc.contributor.authorSait, A.
dc.contributor.authorKorkmaz, S.
dc.date.accessioned2026-02-28T12:18:10Z
dc.date.available2026-02-28T12:18:10Z
dc.date.issued2024
dc.departmentBayburt Üniversitesi
dc.description.abstractBackground: The aim of this study was to investigate the effects of STZ (Streptozotocin) and Rambutan peel extract (RPE) on serum visfatin and cardiac response in experimental Type 2 diabetic rats. Methods: In this study, 64 adult male Wistar albino rats, aged between 8-10 weeks, were used. 8 groups were randomly selected, each containing 8 rats as Control (C), R100 (RPE 100 mg/kg group given with oral gavage route of administration (OGRA), R200 (RPE 200 mg/kg group given with OGRA), R300 (RPE 300 mg/kg group given with OGRA); Diabetes Control (DC): STZ 50 mg/kg i.p administered group, DR100 (D+100 mg/kg JPE), DR200 (D+200 mg/kg JPE), DR300 (D+300 mg/kg JPE). The study lasted a total of 31 days, including adaptation (7 days), induction of diabetes (3 days) and trial period (21 days). Blood samples were taken from the tail vein (vena caudalis) of all subjects on days 0 and 21 of the study. Visfatin and cTnI levels in the serum samples were measured and evaluated by ELISA method. Result: While the increase in mean serum visfatin and cTnI levels in diabetic groups was seen mostly in DC groups, the most significant decrease in mean serum visfatin level due to the addition of RPE was determined in DR100 groups (p<0.01). As a result, it was concluded that the administration of 100 mg/kg RPE in rats had no adverse effects. It was concluded that RPE, which has a cardioprotective effect by regulating the visfatin response that plays a role in the development of diabetes, may be useful in supporting the impaired cardiovascular system function that occurs in diabetes.
dc.description.sponsorshipTurkish Health Institutes Presidency (TUSEB) [21339]
dc.description.sponsorshipThis study was supported by the Turkish Health Institutes Presidency (TUSEB) (Project Number: 21339). The author would like to thank Ufuk UELKER (Assist. Prof. Dr.) and Sevil BAYRAKTAR (MSc) for helping at different project stages.
dc.identifier.doi10.18805/IJAR.BF-1899
dc.identifier.endpage1974
dc.identifier.issn0367-6722
dc.identifier.issue11
dc.identifier.scopus2-s2.0-85210380815
dc.identifier.scopusqualityQ3
dc.identifier.startpage1969
dc.identifier.urihttps://doi.org/10.18805/IJAR.BF-1899
dc.identifier.urihttps://hdl.handle.net/20.500.12403/6140
dc.identifier.volume58
dc.identifier.wosWOS:001364561400021
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAgricultural Research Communication Centre
dc.relation.ispartofIndian Journal of Animal Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260218
dc.subjectCardiac troponin
dc.subjectRambutan
dc.subjectRat
dc.subjectType 2 Diabetes mellitus
dc.subjectVisfatin.
dc.titleEffect of Different Rates of Rambutan Peel Extract on Visfatin and Cardiac Troponi N I Response in Type 2 Diabetic Rats Induced with Streptozotocin
dc.typeArticle

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