The anti-genotoxic effect of some lichenic acids
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
National Science Foundation
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Four lichen secondary metabolites; diffractaic acid, lecanoric acid, lobaric acid and vulpinic acid were evaluated for the anti-genotoxic effects on human lymphocytes in vitro using single cell gel electrophoresis (SCGE) or comet assay. Carbon tetrachloride, a known mutagenic agent was used as the positive control in the comet test system. The results revealed that at all concentrations, the tested compounds mediated a significant decrease in total DNA damage (comet assay) as compared with positive controls (p > 0.05). The most effective doses of lichen acids were found to be 100 ?gmL-1 of diffractic acid, lobaric acid and vulpinic acid, and 50 ?gmL-1 of lecanoric acid. In addition, it was determined that the most effective among the tested compounds was vulpinic acid. © 2018, National Science Foundation. All rights reserved.
Açıklama
Anahtar Kelimeler
Antigenotoxic activity, Comet assay, Diffractaic acid, Lecanoric acid, Lichen compounds, Lobaric acid, Vulpinic acid, Antigenotoxic activity, Comet assay, Diffractaic acid, Lecanoric acid, Lichen compounds, Lobaric acid, Vulpinic acid
Kaynak
Journal of the National Science Foundation of Sri Lanka
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
46
Sayı
2
