The anti-genotoxic effect of some lichenic acids

Küçük Resim Yok

Tarih

2018

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

National Science Foundation

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Four lichen secondary metabolites; diffractaic acid, lecanoric acid, lobaric acid and vulpinic acid were evaluated for the anti-genotoxic effects on human lymphocytes in vitro using single cell gel electrophoresis (SCGE) or comet assay. Carbon tetrachloride, a known mutagenic agent was used as the positive control in the comet test system. The results revealed that at all concentrations, the tested compounds mediated a significant decrease in total DNA damage (comet assay) as compared with positive controls (p > 0.05). The most effective doses of lichen acids were found to be 100 ?gmL-1 of diffractic acid, lobaric acid and vulpinic acid, and 50 ?gmL-1 of lecanoric acid. In addition, it was determined that the most effective among the tested compounds was vulpinic acid. © 2018, National Science Foundation. All rights reserved.

Açıklama

Anahtar Kelimeler

Antigenotoxic activity, Comet assay, Diffractaic acid, Lecanoric acid, Lichen compounds, Lobaric acid, Vulpinic acid, Antigenotoxic activity, Comet assay, Diffractaic acid, Lecanoric acid, Lichen compounds, Lobaric acid, Vulpinic acid

Kaynak

Journal of the National Science Foundation of Sri Lanka

WoS Q Değeri

Q4

Scopus Q Değeri

Q3

Cilt

46

Sayı

2

Künye