Evaluation of miR-130b-3p and miR-375 levels and telomere length with telomerase activity in prostate cancer

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dc.authoridLucke-Wold, Brandon/0000-0001-6577-4080
dc.contributor.authorKaradag, Abdullah
dc.contributor.authorDirican, Ebubekir
dc.contributor.authorOzmerdiven, Cagdas Gokhun
dc.contributor.authorOzen, Ata
dc.contributor.authorAyan, Semih
dc.contributor.authorKabadere, Selda
dc.date.accessioned2024-10-04T18:49:47Z
dc.date.available2024-10-04T18:49:47Z
dc.date.issued2024
dc.departmentBayburt Üniversitesien_US
dc.description.abstractProstate cancer (PC) is the most frequent cancer in males, as well as the second highest cause of cancer-related deaths in men. Differences in expression levels of miRNAs were linked with prostat cancer pathogenesis. qPCR was used to evaluate the expression of miR-130b-3p and miR-375 in Benign Prostate Hyperplasia (BPH (n = 20) and PC (n = 22, pre- and post-operative) patients plasma. Relative telomere lengths (RLTs) in genomic DNA isolated from plasma were measured with qPCR, and telomerase activity analyzed by the ELISA method. PSA levels of PC patients were greater than of BPH patients (p = 0.0473). miR-130b-3p and miR-375 levels were significantly lower in pre-operative specimens of PC patients according to BPH (p = 0,0362, p = 0.0168, respectively). Similarly, post-operative miR-375 levels were lower in PC patients than in BPH patients (p = 0.1866). BPH patients had shorter RTLs than PC patients in both pre- (p=0.0438) and post-operative (p=0.0297) specimens. Telomerase activity was higher in PC patients than BPH(p = 0.0129). Interestingly, telomerase activity was further increased after surgery (p = 0.0003). We aim to identify the levels of miR-130b-3p and miR-375 expression and their relationship with telomerase activity in PC patients. Our data suggest that miRNAs and telomere length (TL) with telomerase activity may play a role in regulating prostate tumorgenesis and may be used as biomarkers for PC diagnosis.en_US
dc.identifier.doi10.1080/15257770.2024.2334896
dc.identifier.issn1525-7770
dc.identifier.issn1532-2335
dc.identifier.pmid38593055en_US
dc.identifier.scopus2-s2.0-85190437266en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1080/15257770.2024.2334896
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3280
dc.identifier.wosWOS:001200456500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofNucleosides Nucleotides & Nucleic Acidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProstate canceren_US
dc.subjectmiR-130b-3pen_US
dc.subjectmiR-375en_US
dc.subjecttelomere lengthen_US
dc.subjecttelomerase activityen_US
dc.titleEvaluation of miR-130b-3p and miR-375 levels and telomere length with telomerase activity in prostate canceren_US
dc.typeArticleen_US

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