Hot injection synthesis of metal-doped Ag2S nanocrystals: A novel multifunctional approach for cancer therapy, antibacterial strategies, and antioxidant defense

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dc.contributor.authorUlusu, Funda
dc.contributor.authorOzel, Sultan Suleyman
dc.contributor.authorSarilmaz, Adem
dc.contributor.authorUlusu, Yakup
dc.date.accessioned2026-09-01T15:53:10Z
dc.date.available2026-09-01T15:53:10Z
dc.date.issued2026
dc.departmentBayburt Üniversitesi
dc.description.abstractThis pioneering study presents the synthesis and comprehensive evaluation of bare and metal-doped Ag2S nanocrystals (NCs) as multifunctional agents with potential applications in antibacterial, antioxidant, and anticancer therapies. The incorporation of manganese, nickel, cobalt, and zinc into Ag2S NCs resulted in a notable enhancement of their bioactivity, representing a novel approach in nanomaterial design. The antibacterial assessments revealed that Mn:Ag2S NCs were the most potent candidate, exhibiting exceptional activity against S. aureus and E. coli, with the lowest MIC values recorded at 1.28 mg/mL and 1.08 mg/mL, respectively. The antioxidant studies demonstrated that the Mn:Ag2S NCs exhibited remarkable free radical scavenging and ferric reducing capacities, with the lowest IC50 values (22.69 mu g/mL for DPPH and 61.31 mu g/mL for FRAP) underscoring their potential to mitigate oxidative stress. Importantly, cytotoxicity assays revealed that Ni:Ag2S and Mn:Ag2S nanocrystals selectively inhibited the proliferation of human colon cancer cells (HT-29), achieving IC50 values of 61.51 mu g/mL and 90.12 mu g/mL, respectively. Furthermore, these NCs demonstrate reduced toxicity towards mouse fibroblast cells (L929). This selective cytotoxicity indicates the potential of these agents in targeted cancer therapies, thereby reducing damage to healthy tissues. To the best of our knowledge, this is the first study to systematically explore the synergistic effects of metal doping on the multifunctional properties of Ag2S NCs. These findings provide a robust basis for further in vivo studies and offer new avenues for the development of safe and effective nanomaterials in biomedical applications, particularly as antimicrobial, antioxidant, and anticancer agents.
dc.identifier.doi10.1007/s10971-025-07078-9
dc.identifier.issn0928-0707
dc.identifier.issn1573-4846
dc.identifier.issue2
dc.identifier.orcid0000-0002-3935-9649
dc.identifier.scopus2-s2.0-105029484578
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.1007/s10971-025-07078-9
dc.identifier.urihttps://hdl.handle.net/20.500.12403/8554
dc.identifier.volume117
dc.identifier.wosWOS:001682508100006
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Sol-Gel Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260820
dc.subjectAg2S Nanocrystals
dc.subjectCancer Therapy
dc.subjectAntibacterial Activity
dc.subjectAntioxidant Activity
dc.titleHot injection synthesis of metal-doped Ag2S nanocrystals: A novel multifunctional approach for cancer therapy, antibacterial strategies, and antioxidant defense
dc.typeArticle

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