Protective Role of Mentha longifolia L. ssp. longifolia against Aflatoxin B

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dc.authorid53983736200
dc.authorid7003921401
dc.authorid26639133600
dc.authorid55490650200
dc.authorid55771966200
dc.authorid6602387040
dc.contributor.authorCeker S.
dc.contributor.authorAgar G.
dc.contributor.authorAlpsoy L.
dc.contributor.authorNardemir G.
dc.contributor.authorKizil H.E.
dc.contributor.authorMete E.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:44:25Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:44:25Z
dc.date.issued2013
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effects of essential oil of Mentha longifolia L. ssp. longifolia, used since ancient times for the treatment of many digestive tract diseases, on the genotoxicity and oxidative stress by a single dose of Aflatoxin B1 (5 ?M) in the human lymphocyte culture. The total of the 12 identified components accounted for 97.69 % by Gas chromatography (GC). Major components of the oil were cis-piperitone epoxide (26.52 %), piperitenone oxide (26.40 %), pulegone (15.66 %) and piperitenone (13.57 %). According to the results obtained from GC-MS systems, monoterpenes consist of 89.19 % of the total oil approximately while sesquiterpenes were represented in small quantities in the oil. We studied the anti-genotoxic effects of essential oils of M. longifolia (MEO) by using sister chromatid exchange (SCE) and micronucleus (MN) test systems. Also, the anti-oxidative effects of MEO were evaluated by using superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA) assay. The SCE frequency and the number of MN were increased when treated with AFB1. Especially, MEO at 1.5 and 2.0 ?l reduced SCE frequency and MN number in the human lymphocyte (p <0.05). In addition, AFB1 treatment significantly reduced the activity of SOD and GPx and elevated the level of MDA (p<0.05). MEOs treatment led to significant attenuation of AFB1-induced oxidative stress by normalization of the activities of SOD and GPx and the MDA (p < 0.05). These results suggest that MEOs could provide anti-oxidative and anti-genotoxic protection for the oxidative and genotoxic agents that cause many diseases including cancer and neurodegenerative disease. © 2013 Har Krishan Bhalla & Sons.en_US
dc.identifier.doi10.1080/0972060X.2013.854487
dc.identifier.endpage607
dc.identifier.issn0972-060X
dc.identifier.issue5
dc.identifier.scopus2-s2.0-84889650547en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage600
dc.identifier.urihttps://dx.doi.org/10.1080/0972060X.2013.854487
dc.identifier.urihttps://hdl.handle.net/20.500.12403/852
dc.identifier.volume16
dc.identifier.wosWOS:000327587900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Essential Oil-Bearing Plantsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaflatoxin B1
dc.subjectanti-oxidative system
dc.subjectgenotoxicity
dc.subjectMentha longifolia
dc.subjectaflatoxin B1
dc.subjectanti-oxidative system
dc.subjectgenotoxicity
dc.subjectMentha longifolia
dc.titleProtective Role of Mentha longifolia L. ssp. longifolia against Aflatoxin Ben_US
dc.typeArticleen_US

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