The Relationship Between Metacognitive Beliefs and Salivary Cortisol, BDNF, and NDNF Levels: A Cross-Sectional Study

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dc.authorid0000-0002-0242-5921
dc.authorid0000-0002-2335-9089
dc.contributor.authorOkur, Suheyb
dc.contributor.authorBayraktar, Bulent
dc.contributor.authorKose, Fatma Tosun
dc.date.accessioned2026-02-28T12:17:40Z
dc.date.available2026-02-28T12:17:40Z
dc.date.issued2025
dc.departmentBayburt Üniversitesi
dc.description.abstractPurpose The main objective of this study is to non-invasively investigate the relationship between metacognitive beliefs and cortisol, the primary stress output of the hypothalamic-pituitary-adrenal (HPA) axis, as well as neurotrophic factors associated with neuroplasticity brain-derived neurotrophic factor and neuron-derived neurotrophic factor (BDNF and NDNF). Within this framework, the hypotheses that negative metacognitions would be associated with increased cortisol and decreased BDNF levels, and that cortisol might play a mediating role in this relationship, were tested.Method The study was designed in a cross-sectional model with 60 university students. Participants' metacognitive beliefs were measured using the Metacognitions Questionnaire-30 (MCQ-30). Salivary cortisol, BDNF, and NDNF levels were analyzed using the ELISA method. Pearson correlation and hierarchical multiple regression analyses were used for data analysis.Finding The results showed a significant positive relationship between the total metacognition score and cortisol (r = 0.589, p < 0.01) and a strong negative relationship between cortisol and BDNF (r = -0.662, p < 0.01). Hierarchical regression analysis supported a partial mediation model, indicating that dysfunctional metacognitive beliefs have both a significant direct negative association with BDNF and an indirect association mediated by cortisol. In the final model, both metacognition (beta = -0.298, p < 0.05) and cortisol (beta = -0.281, p < 0.05) were significant factors associated with lower BDNF levels. NDNF showed a positive relationship with BDNF (r = 0.571) but not with other variables.Conclusion These findings point to a psychobiological model where dysfunctional metacognitive beliefs are linked to suppressed neuroprotective mechanisms like BDNF, both directly and indirectly through HPA axis activation. The results shed light on the potential neurobiological mechanisms underlying the effectiveness of metacognitive therapies.
dc.identifier.doi10.1002/brb3.71063
dc.identifier.issn2162-3279
dc.identifier.issue12
dc.identifier.pmid41376183
dc.identifier.scopus2-s2.0-105024609633
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/brb3.71063
dc.identifier.urihttps://hdl.handle.net/20.500.12403/5899
dc.identifier.volume15
dc.identifier.wosWOS:001636712100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBrain And Behavior
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260218
dc.subjectBDNF
dc.subjectbiomarker
dc.subjectcortisol
dc.subjectmetacognition
dc.subjectNDNF
dc.titleThe Relationship Between Metacognitive Beliefs and Salivary Cortisol, BDNF, and NDNF Levels: A Cross-Sectional Study
dc.typeArticle

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