Synthesis and Biological Evaluation of Novel Tricyclic Pyrrolidinyl (R)?Alcohols and Amines
Küçük Resim Yok
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
The Journal of Heterocyclic Chemistry
Erişim Hakkı
Özet
Three new tricyclic pyrrolidinyl alcohols and three tricyclic pyrrolidinyl amines were synthesized, and the antibacterial activities of these compounds were tested against Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli O157:H7, Staphylococcus aureus, and Listeria monocytogenes. All tested pyrrolidinyl alcohols and amines showed antibacterial activity to the tested pathogens, but this activity was dependent on the final concentration of the tested compound, and the structure of these compounds were also important for this antibacterial activity. Of the tested compounds, (2R)‐2‐(octahydro‐4,8‐ethanocyclohepta[c]pyrrol‐2(1H)‐yl)‐2‐phenylethanamine (2c) was the most effective compound among the tested pyrrolidinyl alcohols and amines. This study shows a good example of finding new antimicrobials in order to control pathogenic bacteria.
Açıklama
Anahtar Kelimeler
antibacterial activity, amino alcohol, tricyclic pyrrolidinyl alcohols
Kaynak
The Journal of Heterocyclic Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
56
Sayı
63
Künye
Şahin, E., Kılıç, H., Törnük, F., & Dertli, E. (2019). Synthesis and Biological Evaluation of Novel Tricyclic Pyrrolidinyl (R)‐Alcohols and Amines. Journal of Heterocyclic Chemistry, 56(3), 824-831.
