Synthesis and Biological Evaluation of Novel Tricyclic Pyrrolidinyl (R)?Alcohols and Amines

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dc.authorid0000-0002-3723-1705en_US
dc.contributor.authorŞahin, Engin
dc.contributor.authorKılıç, Hamdullah
dc.contributor.authorTörnük. Fatih
dc.contributor.authorDertli, Enes
dc.date.accessioned2020-11-25T19:52:15Z
dc.date.available2020-11-25T19:52:15Z
dc.date.issued2019en_US
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractThree new tricyclic pyrrolidinyl alcohols and three tricyclic pyrrolidinyl amines were synthesized, and the antibacterial activities of these compounds were tested against Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli O157:H7, Staphylococcus aureus, and Listeria monocytogenes. All tested pyrrolidinyl alcohols and amines showed antibacterial activity to the tested pathogens, but this activity was dependent on the final concentration of the tested compound, and the structure of these compounds were also important for this antibacterial activity. Of the tested compounds, (2R)‐2‐(octahydro‐4,8‐ethanocyclohepta[c]pyrrol‐2(1H)‐yl)‐2‐phenylethanamine (2c) was the most effective compound among the tested pyrrolidinyl alcohols and amines. This study shows a good example of finding new antimicrobials in order to control pathogenic bacteria.en_US
dc.identifier.citationŞahin, E., Kılıç, H., Törnük, F., & Dertli, E. (2019). Synthesis and Biological Evaluation of Novel Tricyclic Pyrrolidinyl (R)‐Alcohols and Amines. Journal of Heterocyclic Chemistry, 56(3), 824-831.en_US
dc.identifier.doi10.1002/jhet.3457
dc.identifier.endpage831en_US
dc.identifier.issue63en_US
dc.identifier.scopus2-s2.0-85060338348en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage824en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/jhet.3457?casa_token=zuxeh-nbvnUAAAAA%3A1BEYYliDjIwmXU0NhhNU28BAT6e49Naw_wux7uDsQ0MKwCPpvqHw_hHG6ilqUa8xQbi2UQcXm4r1o8Ws
dc.identifier.urihttps://hdl.handle.net/20.500.12403/2227
dc.identifier.volume56en_US
dc.identifier.wosWOS:000461906200010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherThe Journal of Heterocyclic Chemistryen_US
dc.relation.ispartofThe Journal of Heterocyclic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectantibacterial activityen_US
dc.subjectamino alcoholen_US
dc.subjecttricyclic pyrrolidinyl alcoholsen_US
dc.titleSynthesis and Biological Evaluation of Novel Tricyclic Pyrrolidinyl (R)?Alcohols and Aminesen_US
dc.typeArticleen_US

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