Effect of boric acid, calcium fructoborate and potassium boron citrate on bone health and systemic inflammatory markers in rats
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Energy Nuclear and Mining Research Institute
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of this study was to examine the effects of boron compounds on bone health. For this purpose, twenty-four Wistar rats were used. The animals were divided into four groups the control group and the groups to which boron varieties were administered. Three groups were given 3 mg/kg boric acid (BA), calcium fructoborate (CaFB), and potassium boron citrate (KBCi) orally by gavage for three weeks. TNF-?, IL1-?, total antioxidant level (TAS), total oxidant level (TOS), osteopontin, and osteocalcin levels were measured in serum and bone tissues of animals by ELISA method. There was no significant difference between the groups for TNF-?, IL-1? and TOS levels, and serum osteopontin and osteocalcin levels in the serum samples and bone tissues obtained from the control group and rat groups to which boron compounds were administered (p>0.05). When the serum TAS level was compared to the control group and BA, CaFB, and KBCi applied groups, it showed a significant increase in the groups to which boron compounds were administered (p<0.0001). Bone TAS level was also found to be relatively high in the groups treated with boron varieties (p=0.0005). Bone tissue osteopontin and osteocalcin values increased with the application of BA, CaFB, and KBCi (p<0.0001). The effects of BA, CaFB, and KBCi on bone health have been compared in this study. This study is promising as a preliminary study for more comprehensive studies to be carried out in order to use boron compounds such as BA, CaFB, and KBCi more widely in the future in order to improve bone health, and prevent bone diseases or cope with increased stress due to various factors. © 2023, Turkish Energy Nuclear and Mining Research Institute. All rights reserved.
Açıklama
Anahtar Kelimeler
Boric acid, Calcium fructoborate, Osteocalcin, Osteopontin, Potassium boron citrate
Kaynak
Journal of Boron
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
8
Sayı
1
