Effect of boric acid, calcium fructoborate and potassium boron citrate on bone health and systemic inflammatory markers in rats

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dc.contributor.authorUzunçakmak, Sevgi Karabulut
dc.date.accessioned2024-10-04T18:58:39Z
dc.date.available2024-10-04T18:58:39Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThe aim of this study was to examine the effects of boron compounds on bone health. For this purpose, twenty-four Wistar rats were used. The animals were divided into four groups the control group and the groups to which boron varieties were administered. Three groups were given 3 mg/kg boric acid (BA), calcium fructoborate (CaFB), and potassium boron citrate (KBCi) orally by gavage for three weeks. TNF-?, IL1-?, total antioxidant level (TAS), total oxidant level (TOS), osteopontin, and osteocalcin levels were measured in serum and bone tissues of animals by ELISA method. There was no significant difference between the groups for TNF-?, IL-1? and TOS levels, and serum osteopontin and osteocalcin levels in the serum samples and bone tissues obtained from the control group and rat groups to which boron compounds were administered (p>0.05). When the serum TAS level was compared to the control group and BA, CaFB, and KBCi applied groups, it showed a significant increase in the groups to which boron compounds were administered (p<0.0001). Bone TAS level was also found to be relatively high in the groups treated with boron varieties (p=0.0005). Bone tissue osteopontin and osteocalcin values increased with the application of BA, CaFB, and KBCi (p<0.0001). The effects of BA, CaFB, and KBCi on bone health have been compared in this study. This study is promising as a preliminary study for more comprehensive studies to be carried out in order to use boron compounds such as BA, CaFB, and KBCi more widely in the future in order to improve bone health, and prevent bone diseases or cope with increased stress due to various factors. © 2023, Turkish Energy Nuclear and Mining Research Institute. All rights reserved.en_US
dc.identifier.doi10.30728/boron.1142574
dc.identifier.endpage15en_US
dc.identifier.issn2149-9020
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85164625420en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage9en_US
dc.identifier.trdizinid1185838en_US
dc.identifier.urihttps://doi.org/10.30728/boron.1142574
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1185838
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3951
dc.identifier.volume8en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherTurkish Energy Nuclear and Mining Research Instituteen_US
dc.relation.ispartofJournal of Boronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBoric aciden_US
dc.subjectCalcium fructoborateen_US
dc.subjectOsteocalcinen_US
dc.subjectOsteopontinen_US
dc.subjectPotassium boron citrateen_US
dc.titleEffect of boric acid, calcium fructoborate and potassium boron citrate on bone health and systemic inflammatory markers in ratsen_US
dc.title.alternativeSıçanlarda borik asit, kalsiyum fruktoborat ve potasyum bor sitratın kemik sağlığı ve sistemik inflamatuvar belirteçler üzerine etkisien_US
dc.typeArticleen_US

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