Antioxidant properties and aldose reductase inhibitory potency of Viscum album L. extracts: experimental and computational insights

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dc.contributor.authorAkyuz, Bilal
dc.contributor.authorSengul, Bulent
dc.date.accessioned2024-10-04T18:48:17Z
dc.date.available2024-10-04T18:48:17Z
dc.date.issued2024
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThis study systematically investigates the antioxidant capacity and inhibitory impact of Viscum album L. plant extracts on the aldose reductase (AR) enzyme through a combined approach of in vitro and in silico methods. Various sections derived from distinct plant parts were examined, revealing potent inhibitory potential. Notably, the methanol extract sourced from the plant's stem displayed remarkable efficacy with an IC50 value of 0.156 mu M. Total phenolic content and antioxidant capacity analyses were conducted, highlighting variations across plant parts and solvent types. Qualitative and quantitative phenolic compound content in the extracts was elucidated by LC-MS/MS analysis, revealing higher levels of quinic acid, fumaric acid, and chlorogenic acid. Molecular docking studies further substantiated the inhibitory roles of key compounds like chlorogenic acid and fumaric acid, elucidating their interactions with specific amino acid residues within the AR enzyme's active site and shedding light on the underlying mechanisms. Collectively, this study underscores Viscum album L. extracts as promising candidates for aldose reductase modulation. By merging experimental and computational techniques, the study presents a holistic understanding of natural compound interactions, potentially influencing drug development and herbal therapeutics.en_US
dc.identifier.doi10.55730/1300-011X.3182
dc.identifier.issn1300-011X
dc.identifier.issn1303-6173
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85190890672en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.55730/1300-011X.3182
dc.identifier.urihttp://hdl.handle.net/20.500.12403/2999
dc.identifier.volume48en_US
dc.identifier.wosWOS:001201410500011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Agriculture and Forestryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectViscum album L.en_US
dc.subjectaldose reductaseen_US
dc.subjectherbal medicineen_US
dc.subjectdiabetic complicationsen_US
dc.titleAntioxidant properties and aldose reductase inhibitory potency of Viscum album L. extracts: experimental and computational insightsen_US
dc.typeArticleen_US

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