Genotoxic and antigenotoxic potentials of two Usnea species
Küçük Resim Yok
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
For ages, lichens have long been investigated popularly for biological roles, mainly antitumor, antimicrobial and antioxidant activities. Many positive results were obtained in these previous research. Thus, in this study, we aimed to determine whether extracts of Usnea articulata (UAE) and Usnea filipendula (UFE) possessing a protection against aflatoxin B1(AFB1)-induced genotoxic and oxidative damage. The results of our studies showed that 5 ?M concentrations of AFB1increased the frequencies of sister chromatid exchange (SCE) and the level of malondialdehyde (MDA) and decreased the activities of superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GPx). However, when 5, 10 and 20 µg/mL concentrations of UAE and UFE was added to AFB1, the frequencies of SCE and MDA level were decreased and SOD, GSH and GPx level were increased. The Ames (Salmonella typhimurium TA1535, TA1537) and WP2 (Escherichia coli) test systems carried out evinced that UAE and UFE possess any mutagenicity, but have antimutagenic effects. Consequently, the results of this experiment have clearly shown that UAE and UFE have strong antioxidative and antigenotoxic effects that are associated with its antioxidant nature. A detailed study can be performed to determine the antioxidant properties of each compound that will extend the use of lichen extracts in food and pharmacy industries. © 2013, SAGE Publications. All rights reserved.
Açıklama
Anahtar Kelimeler
AMES, antigenotoxicity, antioxidant enzymes, SCE, Usnea articulata, Usnea filipendula, WP2, aflatoxin B1, antimutagenic agent, antioxidant, glutathione, glutathione peroxidase, malonaldehyde, mutagenic agent, superoxide dismutase, aminoacridine, antimutagenic agent, antioxidant, glutathione, glutathione peroxidase, malonaldehyde, methanol, methylnitronitrosoguanidine, plant extract, sodium azide, superoxide dismutase, unclassified drug, Usnea articulata extract, Usnea filipendula extract, chemistry, DNA damage, drug effects, Escherichia coli, metabolism, oxidative stress, Salmonella enterica serovar Typhimurium, sister chromatid exchange, Usnea, adult, Ames test, antigenotoxic activity, antioxidant activity, Article, concentration (parameters), controlled study, drug activity, Escherichia coli test, genotoxicity, human, human cell, lipid peroxidation, mutagen testing, mutagenicity, nonhuman, normal human, protection, solvent extraction, species, Usnea, Usnea articulata, Usnea filipendula, Aflatoxin B1, Antimutagenic Agents, Antioxidants, DNA Damage, Escherichia coli, Glutathione, Glutathione Peroxidase, Malondialdehyde, Mutagens, Oxidative Stress, Salmonella typhimurium, Sister Chromatid Exchange, Superoxide Dismutase, Usnea, AMES, antigenotoxicity, antioxidant enzymes, SCE, Usnea articulata, Usnea filipendula, WP2, aflatoxin B1, antimutagenic agent, antioxidant, glutathione, glutathione peroxidase, malonaldehyde, mutagenic agent, superoxide dismutase, aminoacridine, antimutagenic agent, antioxidant, glutathione, glutathione peroxidase, malonaldehyde, methanol, methylnitronitrosoguanidine, plant extract, sodium azide, superoxide dismutase, unclassified drug, Usnea articulata extract, Usnea filipendula extract, chemistry, DNA damage, drug effects, Escherichia coli, metabolism, oxidative stress, Salmonella enterica serovar Typhimurium, sister chromatid exchange, Usnea, adult, Ames test, antigenotoxic activity, antioxidant activity, Article, concentration (parameters), controlled study, drug activity, Escherichia coli test, genotoxicity, human, human cell, lipid peroxidation, mutagen testing, mutagenicity, nonhuman, normal human, protection, solvent extraction, species, Usnea, Usnea articulata, Usnea filipendula, Aflatoxin B1, Antimutagenic Agents, Antioxidants, DNA Damage, Escherichia coli, Glutathione, Glutathione Peroxidase, Malondialdehyde, Mutagens, Oxidative Stress, Salmonella typhimurium, Sister Chromatid Exchange, Superoxide Dismutase, Usnea
Kaynak
Toxicology and Industrial Health
WoS Q Değeri
Q2
Scopus Q Değeri
Q3
Cilt
31
Sayı
11
