Genotoxic and antigenotoxic potentials of two Usnea species

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dc.authorid53983736200
dc.authorid36128059200
dc.authorid55771966200
dc.authorid26639133600
dc.authorid6602542681
dc.authorid7102214656
dc.authorid7003921401
dc.contributor.authorCeker S.
dc.contributor.authorOrhan F.
dc.contributor.authorKizil H.E.
dc.contributor.authorAlpsoy L.
dc.contributor.authorGulluce M.
dc.contributor.authorAslan A.
dc.contributor.authorAgar G.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:44:06Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:44:06Z
dc.date.issued2015
dc.departmentBayburt Üniversitesien_US
dc.description.abstractFor ages, lichens have long been investigated popularly for biological roles, mainly antitumor, antimicrobial and antioxidant activities. Many positive results were obtained in these previous research. Thus, in this study, we aimed to determine whether extracts of Usnea articulata (UAE) and Usnea filipendula (UFE) possessing a protection against aflatoxin B1(AFB1)-induced genotoxic and oxidative damage. The results of our studies showed that 5 ?M concentrations of AFB1increased the frequencies of sister chromatid exchange (SCE) and the level of malondialdehyde (MDA) and decreased the activities of superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GPx). However, when 5, 10 and 20 µg/mL concentrations of UAE and UFE was added to AFB1, the frequencies of SCE and MDA level were decreased and SOD, GSH and GPx level were increased. The Ames (Salmonella typhimurium TA1535, TA1537) and WP2 (Escherichia coli) test systems carried out evinced that UAE and UFE possess any mutagenicity, but have antimutagenic effects. Consequently, the results of this experiment have clearly shown that UAE and UFE have strong antioxidative and antigenotoxic effects that are associated with its antioxidant nature. A detailed study can be performed to determine the antioxidant properties of each compound that will extend the use of lichen extracts in food and pharmacy industries. © 2013, SAGE Publications. All rights reserved.en_US
dc.identifier.doi10.1177/0748233713485889
dc.identifier.endpage999
dc.identifier.issn0748-2337
dc.identifier.issue11
dc.identifier.pmid23589403en_US
dc.identifier.scopus2-s2.0-84945128430en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage990
dc.identifier.urihttps://dx.doi.org/10.1177/0748233713485889
dc.identifier.urihttps://hdl.handle.net/20.500.12403/769
dc.identifier.volume31
dc.identifier.wosWOS:000363351400004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAMES
dc.subjectantigenotoxicity
dc.subjectantioxidant enzymes
dc.subjectSCE
dc.subjectUsnea articulata
dc.subjectUsnea filipendula
dc.subjectWP2
dc.subjectaflatoxin B1
dc.subjectantimutagenic agent
dc.subjectantioxidant
dc.subjectglutathione
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectmutagenic agent
dc.subjectsuperoxide dismutase
dc.subjectaminoacridine
dc.subjectantimutagenic agent
dc.subjectantioxidant
dc.subjectglutathione
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectmethanol
dc.subjectmethylnitronitrosoguanidine
dc.subjectplant extract
dc.subjectsodium azide
dc.subjectsuperoxide dismutase
dc.subjectunclassified drug
dc.subjectUsnea articulata extract
dc.subjectUsnea filipendula extract
dc.subjectchemistry
dc.subjectDNA damage
dc.subjectdrug effects
dc.subjectEscherichia coli
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectSalmonella enterica serovar Typhimurium
dc.subjectsister chromatid exchange
dc.subjectUsnea
dc.subjectadult
dc.subjectAmes test
dc.subjectantigenotoxic activity
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectconcentration (parameters)
dc.subjectcontrolled study
dc.subjectdrug activity
dc.subjectEscherichia coli test
dc.subjectgenotoxicity
dc.subjecthuman
dc.subjecthuman cell
dc.subjectlipid peroxidation
dc.subjectmutagen testing
dc.subjectmutagenicity
dc.subjectnonhuman
dc.subjectnormal human
dc.subjectprotection
dc.subjectsolvent extraction
dc.subjectspecies
dc.subjectUsnea
dc.subjectUsnea articulata
dc.subjectUsnea filipendula
dc.subjectAflatoxin B1
dc.subjectAntimutagenic Agents
dc.subjectAntioxidants
dc.subjectDNA Damage
dc.subjectEscherichia coli
dc.subjectGlutathione
dc.subjectGlutathione Peroxidase
dc.subjectMalondialdehyde
dc.subjectMutagens
dc.subjectOxidative Stress
dc.subjectSalmonella typhimurium
dc.subjectSister Chromatid Exchange
dc.subjectSuperoxide Dismutase
dc.subjectUsnea
dc.subjectAMES
dc.subjectantigenotoxicity
dc.subjectantioxidant enzymes
dc.subjectSCE
dc.subjectUsnea articulata
dc.subjectUsnea filipendula
dc.subjectWP2
dc.subjectaflatoxin B1
dc.subjectantimutagenic agent
dc.subjectantioxidant
dc.subjectglutathione
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectmutagenic agent
dc.subjectsuperoxide dismutase
dc.subjectaminoacridine
dc.subjectantimutagenic agent
dc.subjectantioxidant
dc.subjectglutathione
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectmethanol
dc.subjectmethylnitronitrosoguanidine
dc.subjectplant extract
dc.subjectsodium azide
dc.subjectsuperoxide dismutase
dc.subjectunclassified drug
dc.subjectUsnea articulata extract
dc.subjectUsnea filipendula extract
dc.subjectchemistry
dc.subjectDNA damage
dc.subjectdrug effects
dc.subjectEscherichia coli
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectSalmonella enterica serovar Typhimurium
dc.subjectsister chromatid exchange
dc.subjectUsnea
dc.subjectadult
dc.subjectAmes test
dc.subjectantigenotoxic activity
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectconcentration (parameters)
dc.subjectcontrolled study
dc.subjectdrug activity
dc.subjectEscherichia coli test
dc.subjectgenotoxicity
dc.subjecthuman
dc.subjecthuman cell
dc.subjectlipid peroxidation
dc.subjectmutagen testing
dc.subjectmutagenicity
dc.subjectnonhuman
dc.subjectnormal human
dc.subjectprotection
dc.subjectsolvent extraction
dc.subjectspecies
dc.subjectUsnea
dc.subjectUsnea articulata
dc.subjectUsnea filipendula
dc.subjectAflatoxin B1
dc.subjectAntimutagenic Agents
dc.subjectAntioxidants
dc.subjectDNA Damage
dc.subjectEscherichia coli
dc.subjectGlutathione
dc.subjectGlutathione Peroxidase
dc.subjectMalondialdehyde
dc.subjectMutagens
dc.subjectOxidative Stress
dc.subjectSalmonella typhimurium
dc.subjectSister Chromatid Exchange
dc.subjectSuperoxide Dismutase
dc.subjectUsnea
dc.titleGenotoxic and antigenotoxic potentials of two Usnea speciesen_US
dc.typeArticleen_US

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