Comparison of telomere length and insulin-like growth factor-binding protein 7 promoter methylation between breast cancer tissues and adjacent normal tissues in Turkish women

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dc.authorid55876457500
dc.authorid57195257114
dc.authorid55771646300
dc.authorid56448719400
dc.authorid57192116611
dc.authorid7801655696
dc.authorid6603333281
dc.authorid7102340078
dc.authorid7005139386
dc.contributor.authorKaya Z.
dc.contributor.authorAkkiprik M.
dc.contributor.authorKarabulut S.
dc.contributor.authorPeker I.
dc.contributor.authorGullu Amuran G.
dc.contributor.authorOzmen T.
dc.contributor.authorGulluoglu B.M.
dc.contributor.authorKaya H.
dc.contributor.authorOzer A.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:43:16Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:43:16Z
dc.date.issued2017
dc.departmentBayburt Üniversitesien_US
dc.description.abstractBackground: Both insulin-like growth factor-binding protein 7 (IGFBP7) and telomere length (TL) are associated with proliferation and senescence of human breast cancer. This study assessed the clinical significance of both TL and IGFBP7 methylation status in breast cancer tissues compared with adjacent normal tissues. We also investigated whether IGFBP7 methylation status could be affecting TL. Methods: Telomere length was measured by quantitative PCR to compare tumors with their adjacent normal tissues. The IGFBP7 promoter methylation status was evaluated by methylation-specific PCR and its expression levels were determined by western blotting. Results: Telomeres were shorter in tumor tissues compared to controls (P<.0001). The mean TL was higher in breast cancer with invasive ductal carcinoma (IDC; n=72; P=.014) compared with other histological type (n=29), and TL in IDC with HER2 negative (n=53; P=.017) was higher than TL in IDC with HER2 positive (n=19). However, telomeres were shortened in advanced stages and growing tumors. IGFBP7 methylation was observed in 90% of tumor tissues and 59% of controls (P=.0002). Its frequency was significantly higher in IDC compared with invasive mixed carcinoma (IMC; P=.002) and it was not correlated either with protein expression or the other clinicopathological parameters. Conclusion: These results suggest that IGFBP7 promoter methylation and shorter TL in tumor compared with adjacent tissues may be predictive biomarkers for breast cancer. Telomere maintenance may be indicative of IDC and IDC with HER2 (?) of breast cancer. Further studies with larger number of cases are necessary to verify this association. © 2016 Wiley Periodicals, Inc.en_US
dc.identifier.doi10.1002/jcla.22083
dc.identifier.issn0887-8013
dc.identifier.issue5
dc.identifier.pmid27775181en_US
dc.identifier.scopus2-s2.0-84997764869en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1002/jcla.22083
dc.identifier.urihttps://hdl.handle.net/20.500.12403/478
dc.identifier.volume31
dc.identifier.wosWOS:000411716300014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.
dc.relation.ispartofJournal of Clinical Laboratory Analysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbreast cancer
dc.subjectinsulin-like growth factor-binding protein 7
dc.subjectmethylation
dc.subjecttelomere
dc.subjecttelomere length
dc.subjectinsulin like growth factor binding protein 7
dc.subjectsomatomedin binding protein
dc.subjectunclassified drug
dc.subjectinsulin-like growth factor binding protein-related protein 1
dc.subjectsomatomedin binding protein
dc.subjectadult
dc.subjectadvanced cancer
dc.subjectArticle
dc.subjectbreast carcinoma
dc.subjectcancer grading
dc.subjectcancer growth
dc.subjectcancer staging
dc.subjectcancer tissue
dc.subjectcontrolled study
dc.subjectestrogen receptor positive breast cancer
dc.subjectfamily history
dc.subjectfemale
dc.subjecthistology
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman epidermal growth factor receptor 2 positive breast cancer
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmenopause
dc.subjectmixed tumor
dc.subjectpolymerase chain reaction
dc.subjectprogesterone receptor positive breast cancer
dc.subjectprotein expression
dc.subjectprotein methylation
dc.subjecttelomere length
dc.subjecttelomere shortening
dc.subjecttumor invasion
dc.subjectTurk (people)
dc.subjectWestern blotting
dc.subjectbreast
dc.subjectbreast tumor
dc.subjectchemistry
dc.subjectcohort analysis
dc.subjectDNA methylation
dc.subjectgenetics
dc.subjectmiddle aged
dc.subjectmortality
dc.subjectsurvival analysis
dc.subjecttelomere
dc.subjectBreast
dc.subjectBreast Neoplasms
dc.subjectCohort Studies
dc.subjectDNA Methylation
dc.subjectFemale
dc.subjectHumans
dc.subjectInsulin-Like Growth Factor Binding Proteins
dc.subjectMiddle Aged
dc.subjectSurvival Analysis
dc.subjectTelomere
dc.subjectTurkey
dc.subjectbreast cancer
dc.subjectinsulin-like growth factor-binding protein 7
dc.subjectmethylation
dc.subjecttelomere
dc.subjecttelomere length
dc.subjectinsulin like growth factor binding protein 7
dc.subjectsomatomedin binding protein
dc.subjectunclassified drug
dc.subjectinsulin-like growth factor binding protein-related protein 1
dc.subjectsomatomedin binding protein
dc.subjectadult
dc.subjectadvanced cancer
dc.subjectArticle
dc.subjectbreast carcinoma
dc.subjectcancer grading
dc.subjectcancer growth
dc.subjectcancer staging
dc.subjectcancer tissue
dc.subjectcontrolled study
dc.subjectestrogen receptor positive breast cancer
dc.subjectfamily history
dc.subjectfemale
dc.subjecthistology
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman epidermal growth factor receptor 2 positive breast cancer
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmenopause
dc.subjectmixed tumor
dc.subjectpolymerase chain reaction
dc.subjectprogesterone receptor positive breast cancer
dc.subjectprotein expression
dc.subjectprotein methylation
dc.subjecttelomere length
dc.subjecttelomere shortening
dc.subjecttumor invasion
dc.subjectTurk (people)
dc.subjectWestern blotting
dc.subjectbreast
dc.subjectbreast tumor
dc.subjectchemistry
dc.subjectcohort analysis
dc.subjectDNA methylation
dc.subjectgenetics
dc.subjectmiddle aged
dc.subjectmortality
dc.subjectsurvival analysis
dc.subjecttelomere
dc.subjectBreast
dc.subjectBreast Neoplasms
dc.subjectCohort Studies
dc.subjectDNA Methylation
dc.subjectFemale
dc.subjectHumans
dc.subjectInsulin-Like Growth Factor Binding Proteins
dc.subjectMiddle Aged
dc.subjectSurvival Analysis
dc.subjectTelomere
dc.subjectTurkey
dc.titleComparison of telomere length and insulin-like growth factor-binding protein 7 promoter methylation between breast cancer tissues and adjacent normal tissues in Turkish womenen_US
dc.typeArticleen_US

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