Sweet Bones: The Effect of Diabetes Mellitus on Bone Health
Küçük Resim Yok
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Dokuz Eylul University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Diabetes mellitus is a chronic hyperglycemic, common disease with significant mortality and morbidity affecting millions of people worldwide. Besides the well-known complications of diabetes on the cardiovascular system, eyes, kidneys and nervous system, bone is also affected by diabetes. Recently, there is increasing evidence that diabetes affects the skeletal system negatively and has harmful effects on bone, such as impaired bone quality and bone strength, increased risk of fractures and impaired bone healing. Diabetes has a strong impact on bone health, and skeletal fragility is now recognized as a major complication of both Type 1 and Type 2 diabetes. Decrease in bone mineral density in Type 1 diabetes, and deterioration in bone quality and strength, although bone density is normal or higher in Type 2 diabetes, increases the risk of fracture. In the late stages of Type 1 and Type 2 diabetes, insulin deficiency, insufficient release of insulin-like growth factor 1 can disrupt bone homeostasis and lead to fragility. Pathophysiological mechanisms that lead to bone fragility are multifactorial and potentially lead to impaired bone formation, altered bone structure, and reduced bone strength. Interestingly, different antidiabetic treatments can affect fracture risk due to glycemic control, triggering of hypoglycemic events, and effects on bone formation. In this review, the effect of diabetes on bone homeostasis, fracture risk, and the effect of antidiabetic therapy on bone recommendations to healthcare professionals are discussed. © 2022, Dokuz Eylul University. All rights reserved.
Açıklama
Anahtar Kelimeler
Bone Fractures, Diabetes, Diabetic Complications
Kaynak
E-Journal of Dokuz Eylul University Nursing Faculty
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
15
Sayı
2
