Sweet Bones: The Effect of Diabetes Mellitus on Bone Health

Basit Öğe Kaydı
dc.contributor.authorDaştan, Buket
dc.contributor.authorHintistan, Sevilay
dc.date.accessioned2024-10-04T18:58:50Z
dc.date.available2024-10-04T18:58:50Z
dc.date.issued2022
dc.departmentBayburt Üniversitesien_US
dc.description.abstractDiabetes mellitus is a chronic hyperglycemic, common disease with significant mortality and morbidity affecting millions of people worldwide. Besides the well-known complications of diabetes on the cardiovascular system, eyes, kidneys and nervous system, bone is also affected by diabetes. Recently, there is increasing evidence that diabetes affects the skeletal system negatively and has harmful effects on bone, such as impaired bone quality and bone strength, increased risk of fractures and impaired bone healing. Diabetes has a strong impact on bone health, and skeletal fragility is now recognized as a major complication of both Type 1 and Type 2 diabetes. Decrease in bone mineral density in Type 1 diabetes, and deterioration in bone quality and strength, although bone density is normal or higher in Type 2 diabetes, increases the risk of fracture. In the late stages of Type 1 and Type 2 diabetes, insulin deficiency, insufficient release of insulin-like growth factor 1 can disrupt bone homeostasis and lead to fragility. Pathophysiological mechanisms that lead to bone fragility are multifactorial and potentially lead to impaired bone formation, altered bone structure, and reduced bone strength. Interestingly, different antidiabetic treatments can affect fracture risk due to glycemic control, triggering of hypoglycemic events, and effects on bone formation. In this review, the effect of diabetes on bone homeostasis, fracture risk, and the effect of antidiabetic therapy on bone recommendations to healthcare professionals are discussed. © 2022, Dokuz Eylul University. All rights reserved.en_US
dc.identifier.doi10.46483/deuhfed.927575
dc.identifier.endpage245en_US
dc.identifier.issn2149-0333
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85150693529en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage240en_US
dc.identifier.trdizinid1122744en_US
dc.identifier.urihttps://doi.org/10.46483/deuhfed.927575
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1122744
dc.identifier.urihttp://hdl.handle.net/20.500.12403/4054
dc.identifier.volume15en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherDokuz Eylul Universityen_US
dc.relation.ispartofE-Journal of Dokuz Eylul University Nursing Facultyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone Fracturesen_US
dc.subjectDiabetesen_US
dc.subjectDiabetic Complicationsen_US
dc.titleSweet Bones: The Effect of Diabetes Mellitus on Bone Healthen_US
dc.title.alternativeTatlı Kemikler: Diabetes Mellitus’un Kemik Sağlığına Etkisien_US
dc.typeReview Articleen_US

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