Green synthesis of chiral aromatic alcohols with Lactobacillus kefiri P2 as a novel biocatalyst
Küçük Resim Yok
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Synthetic Communications
Erişim Hakkı
Özet
Biocatalytic reduction is a very important field of research in synthetic organic chemistry. Herein, three different Lactic Acid Bacteria (LAB) strains were evaluated for their bioreduction potential using acetophenone as a model substrate. Among these strains, Lactobacillus kefiri P2 strain was determined as the best asymmetric reduction biocatalyst. Reaction optimization parameters such as reaction time, temperature, agitation speed and pH were systematically optimized using Lactobacillus kefiri P2 strain and model substrate acetophenone. Under these optimized reaction conditions, secondary chiral alcohols were obtained by bioreduction of various prochiral ketones with results up to 99% enantiomeric excess. In addition, the steric and electronic effects of substituents on enantioselectivity and conversion were evaluated. It has been shown that Lactobacillus kefiri P2 biocatalyst was an effective catalyst for asymmetric reduction. This method provides an environmentally friendly method for the synthesis of optically pure alcohols and an alternative approach to chemical catalysts.
Açıklama
Anahtar Kelimeler
Chirality, Biotransformation, Lactobacillus kefiri P2
Kaynak
Synthetic Communications
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
50
Sayı
7
Künye
Baydaş, Y., Dertli, E., & Şahin, E. (2020). Green synthesis of chiral aromatic alcohols with Lactobacillus kefiri P2 as a novel biocatalyst. Synthetic Communications, 50(7), 1035-1045.
