Green synthesis of chiral aromatic alcohols with Lactobacillus kefiri P2 as a novel biocatalyst

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dc.authorid0000-0002-3723-1705en_US
dc.contributor.authorBaydaş, Yasemin
dc.contributor.authorDertli, Enes
dc.contributor.authorŞahin, Engin
dc.date.accessioned2020-11-25T19:32:33Z
dc.date.available2020-11-25T19:32:33Z
dc.date.issued2020en_US
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractBiocatalytic reduction is a very important field of research in synthetic organic chemistry. Herein, three different Lactic Acid Bacteria (LAB) strains were evaluated for their bioreduction potential using acetophenone as a model substrate. Among these strains, Lactobacillus kefiri P2 strain was determined as the best asymmetric reduction biocatalyst. Reaction optimization parameters such as reaction time, temperature, agitation speed and pH were systematically optimized using Lactobacillus kefiri P2 strain and model substrate acetophenone. Under these optimized reaction conditions, secondary chiral alcohols were obtained by bioreduction of various prochiral ketones with results up to 99% enantiomeric excess. In addition, the steric and electronic effects of substituents on enantioselectivity and conversion were evaluated. It has been shown that Lactobacillus kefiri P2 biocatalyst was an effective catalyst for asymmetric reduction. This method provides an environmentally friendly method for the synthesis of optically pure alcohols and an alternative approach to chemical catalysts.en_US
dc.identifier.citationBaydaş, Y., Dertli, E., & Şahin, E. (2020). Green synthesis of chiral aromatic alcohols with Lactobacillus kefiri P2 as a novel biocatalyst. Synthetic Communications, 50(7), 1035-1045.en_US
dc.identifier.doi10.1080/00397911.2020.1729809
dc.identifier.endpage1045en_US
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85082546109en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1035en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/00397911.2020.1729809?casa_token=PbRt4vkpwvUAAAAA%3AutKEBlAGSrlPFFCAMdZ2U7WJXhp8um7fVb9NqirJAUMpDuIbHuS48vvJlH9EG5ULoNpeIkMx38IVowU
dc.identifier.urihttps://hdl.handle.net/20.500.12403/2222
dc.identifier.volume50en_US
dc.identifier.wosWOS:000515205500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSynthetic Communicationsen_US
dc.relation.ispartofSynthetic Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectChiralityen_US
dc.subjectBiotransformationen_US
dc.subjectLactobacillus kefiri P2en_US
dc.titleGreen synthesis of chiral aromatic alcohols with Lactobacillus kefiri P2 as a novel biocatalysten_US
dc.typeArticleen_US

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